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Timeless describes moments outside of time - moments that exist so deep inside history that they break through that finite grid. Timeless: The Composer/Arranger Series is an homage to the composer and arrangers that have influenced hip-hop in the most literal and profound ways. The creative center of popular music today is the beatmaker/ producer. Whether it is Timbaland, Dilla, Dre, or Madlib, these musicians have an uncanny sense for voicings, a penchant for unusual sounds and catchy rhythms and a magical ability to manufacture a good performance. Today s beatmakers are the direct descendants of yesterday's composer-arrangers. Their processes -whether it be writing a memorable line for background singers or finding the appropriate moment for a baritone harmonica - mirror those of today's musicians. The composer/arranger creates music through the frame of the bigger picture, often more concerned with how things sound together than individually. Similarly today's beatmakers produce music on a grand scale, but through automation and sampling. Timeless brings these two seemingly unlike worlds together. The series honors the musical legacies of some of the greatest composer and arrangers ever. Timeless celebrates the work in the context it should be seen - with full orchestras. From Mulatu Astatke to J.Dilla to Arthur Verocai, the Timeless Concert Series touched upon the works of three musical giants. Mochilla is proud to announce the release date of their 3xDVD box set. An extremely limited and hand numbered edition of 4,000 units will include full liner notes, a free fold-out poster exclusive only to this box set, extra features, songs and slideshows of images used in the presentation.
Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;